Biotisine
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Mechanism of Action

A step-by-step breakdown of how the formulation survives the harsh gastric environment to reach the lower intestine.

  1. Gastric Transit (Hours 0-2) The hypromellose capsule delays release by approximately 45 minutes, allowing transit through the highly acidic (pH 1.5-3.5) stomach environment.
  2. Duodenal Release (Hours 2-4) As the pH rises in the upper intestine, the capsule dissolves, releasing the freeze-dried bacteria into a hydration state.
  3. Adhesion & Colonization (Hours 4-24) LGG utilizes unique pili (hair-like appendages) to adhere tightly to the mucosal lining, preventing it from being swept away by peristalsis.
Colonization Zone